Symmetrical chromosome rearrangements in cell lines established from human radiation-induced sarcomas
Identifieur interne : 000A68 ( Main/Exploration ); précédent : 000A67; suivant : 000A69Symmetrical chromosome rearrangements in cell lines established from human radiation-induced sarcomas
Auteurs : Janet M. Cowan [États-Unis] ; Michael A. Beckett [États-Unis] ; Nancy Tarbell [États-Unis] ; Ralph R. Weichselbaum [États-Unis]Source :
- Cancer Genetics and Cytogenetics [ 0165-4608 ] ; 1990.
English descriptors
- Teeft :
- Abnormal karyotypes, Additional rearrangements, Balanced translocations, Breast carcinoma, Cancer genet cytogenet, Cell line, Cell lines, Cellular oncology, Chromosome, Chromosome damage, Chromosome number, Complex karyotypes, Continuous time, Cowan, Culture time, Cytogenet, Cytogenetic, Cytogenetic analysis, Dermal fibroblasts, First harvest, Genet, Hypotonic solution, Karyotype, Many years, Marker chromosomes, Modal chromosome number, Molecular analysis, Osteosarcoma, Osteosarcoma samples, Previous reports, Proc natl acad, Radiation therapy, Rearrangement, Retinoblastoma, Same histological type, Sarcoma, Second tumor, Second tumors, Short arms, Soft tissue sarcomas, Solid tumors, Stsar, Synovial sarcoma, Time interval, Translocation, Unidentified markers, Yale university press.
Abstract
Abstract: We report the establishment of cell lines from six radiation-induced tumors, three osteosarcomas, and three soft tissue sarcomas. Cytogenetic analysis of the lines showed mostly balanced rearrangements in the osteosarcomas; the soft tissue sarcomas had more unstable karyotypes. The rearrangements observed were unlike those previously reported for spontaneously occurring tumors of the same histological type and were more typical of the long-term changes observed after radiation exposure.
Url:
DOI: 10.1016/0165-4608(90)90246-7
Affiliations:
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Le document en format XML
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Cytogenetic analysis of the lines showed mostly balanced rearrangements in the osteosarcomas; the soft tissue sarcomas had more unstable karyotypes. The rearrangements observed were unlike those previously reported for spontaneously occurring tumors of the same histological type and were more typical of the long-term changes observed after radiation exposure.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Illinois</li><li>Massachusetts</li></region></list><tree><country name="États-Unis"><region name="Illinois"><name sortKey="Cowan, Janet M" sort="Cowan, Janet M" uniqKey="Cowan J" first="Janet M." last="Cowan">Janet M. Cowan</name></region><name sortKey="Beckett, Michael A" sort="Beckett, Michael A" uniqKey="Beckett M" first="Michael A." last="Beckett">Michael A. Beckett</name><name sortKey="Tarbell, Nancy" sort="Tarbell, Nancy" uniqKey="Tarbell N" first="Nancy" last="Tarbell">Nancy Tarbell</name><name sortKey="Weichselbaum, Ralph R" sort="Weichselbaum, Ralph R" uniqKey="Weichselbaum R" first="Ralph R." last="Weichselbaum">Ralph R. Weichselbaum</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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